Biological Age Tests
Quantifying the pace of aging through methylation, glycans, and clinical biomarkers.
If you cannot measure it, you cannot manage it. The field of biological age testing has evolved rapidly from first-generation clocks (designed to correlate with chronological age) to third-generation clocks (designed to predict mortality and phenotypic changes).
The Modalities
Epigenetic Clocks
Measures DNA methylation patterns (CpG sites). The current gold standard, particularly 3rd-generation algorithms like DunedinPACE.
GlycanAge
Measures IgG glycosylation. Highly responsive to lifestyle changes and systemic inflammation.
Phenotypic Clocks
Uses standard blood panels (Levine PhenoAge) to calculate biological age based on clinical biomarkers.
Comparison Matrix
| Test / Clock | Generation | Analyte | Best For | Cost (Approx) |
|---|---|---|---|---|
| TruAge PACE | 3rd Gen | DNA Methylation | Tracking short-term intervention efficacy | $250 - $400 |
| GrimAge | 2nd Gen | DNA Methylation | Mortality prediction | Varies (Research) |
| GlycanAge | - | IgG Glycans | Inflammation tracking | $350 |
| PhenoAge (Levine) | 1st Gen | Standard Bloods | Free baseline assessment | Free (w/ existing labs) |